贾建博
1989年2月生，籍贯：山东省菏泽市
博士，讲师
大湾区环境研究院
广州大学
广州市越秀区桂花岗东1号广州大学桂花岗校区，510405
E-mail：jb_jia@gzhu.edu.cn
教育背景
2017年毕业于山东大学化学与化工学院，获博士学位
2011年毕业于山东大学生命科学学院，获学士学位
工作经历
2018年3月至今，广州大学大湾区环境研究院环境健康团队，讲师
学术兼职：
中国毒理学会分析毒理专业委员会青年委员（2018.12至今）
Ecotoxicology and Environmental Safety期刊编委（2020至今）
Frontiers in Bioengineering and Biotechnology，Frontiers in Molecular Biosciences期刊 “Nanobiotechnology” Section编委，特邀副主编（2018至今）
研究方向
典型环境污染物健康效应及致毒机制
科研项目
1. 广州市基础研究计划基础与应用基础研究项目（博士青年科技人员类），高环境暴露风险金属基纳米材料的脂代谢干扰效应与机制研究，5万，2021.04-2023.03，主持，在研
2. 国家自然科学基金青年科学基金项目，环境高暴露金属纳米颗粒诱导超重小鼠巨噬细胞炎症响应的分子机制，24万，2020.01-2022.12，主持，在研
3. 广州大学引进人才项目资助项目，微塑料与重金属离子复合暴露对超重小鼠的毒性效应及机制研究，20万，2018.04-2021.03，主持，已结题
4. 国家自然科学基金重点项目，纳米细胞效应的大数据构建及智能模拟预测，300万，2021.01-2025.12，主要参与人（第三位），在研
5. 国家自然科学基金青年科学基金项目，双金属MOF光-Fenton体系的构建及催化降解微污染物的研究，27万，2019.01-2021.12，主要参与人（第二位），在研
6. 国家自然科学基金重大研究计划重点支持项目，细颗粒物与生物界面作用机制的系统探索，290万，2016.01-2019.12，参与，已结题
7. 国家自然科学基金青年科学基金项目，对比羧基化多壁碳纳米管和羧基化石墨烯预暴露对乙型肝炎病毒所致肝损伤的作用研究，25万，2014.01-2016.12，参与，已结题
讲授课程
研究生课程：
《环境毒理学》（32学时）
本科生课程：
《污染物的环境行为和生物效应》（16学时）
《肥胖与环境》（16学时）
发表论文、专著、专利及奖励
共在国内外刊物上发表论文26篇；发表英文专著章节1篇。
ORCID：https://orcid.org/0000-0002-1703-6734
论文：
1. Guohong Liu, Xiliang Yan, Shenqing Wang, Qianhui Yu, Jianbo Jia*, Bing Yan*. Elucidation of the critical role of core materials in PM2.5-induced cytotoxicity by interrogating silica- and carbon-based model PM2.5 particle libraries. Environmental Science & Technology. 2021, 55, 9, 6128–6139.
2. Jianbo Jia, Wei Zhang, Yanxin Wu, Xiaoli Zhang, Chengjun Li, Jingzhou Wang, and Bing Yan*. Mitigation of Obesity-Related Systemic Low-Grade Inflammation and Gut Microbial Dysbiosis in Mice with Nanosilver Supplement. ACS Applied Bio Materials, 2021, 4(3): 2570–2582.
3. Cong Li, Jian Liu, Dujia Wang, Long Kong, Yanxin Wu, Xiaoxia Zhou, Jianbo Jia, Hongyu Zhou*, Bing Yan*. Electrostatic attraction of cationic pollutants by microplastics reduces their joint cytotoxicity. Chemosphere. 2021, 282, 131121.
4. Long Kong, Yanxin Wu, Cong Li, Jian Liu, Jianbo Jia, Hongyu Zhou*, Bing Yan*. Nano-cell and nano-pollutant interactions constitute key elements in nanoparticle-pollutant combined cytotoxicity. Journal of Hazardous Materials. 2021, 418, 126259.
5. Dujia Wang, Xiaoru Yuan, Jianbo Jia, Shuai He, Xiaoxia Zhou*, and Bing Yan. Al3+ reduces PM2.5-induced cytotoxicity in human bronchial epithelial cells via reducing ROS production. Air Quality, Atmosphere & Health. 2021, 14, 903–909.
6. Jianbo Jia, Zengjin Wang, Tongtao Yue, Gaoxing Su, Chuanfeng Teng, Bing Yan*. Crossing Biological Barriers by Engineered Nanoparticles. Chemical Research in Toxicology. 2020, 33: 1055–1060.
7. Jianbo Jia*, Tania Limongi, Yin Liu, Gaoxing Su, & Hongyu Zhou* Editorial: Nano-Bio Interactions: Ecotoxicology and Cytotoxicity of Nanomaterials. Frontiers in Bioengineering and Biotechnology, 2020, 8, 918.
8. Chuanfeng Teng, Jianbo Jia, Zhiping Wang*, BingYan*. Oral co-exposures to zinc oxide nanoparticles and CdCl2 induced maternal-fetal pollutant transfer and embryotoxicity by damaging placental barriers. Ecotoxicology and Environmental Safety. 2020, 189: 109956.
9. Jianbo Jia, Xiaoru Yuan, Xiaowu Peng, Bing Yan*. Cr(VI)/Pb2+ are responsible for PM2.5-induced cytotoxicity in A549 cells while pulmonary surfactant alleviates such toxicity. Ecotoxicology and Environmental Safety. 2019, 172: 152–158.
10. Xiaofei Zhou, Jianbo Jia, Zhen Luo, Gaoxing Su, Tongtao Yue, Bing Yan*. Remote induction of cell autophagy by 2D MoS2 nanosheets via perturbing cell surface receptor and mTOR pathway from outside of cell. ACS Applied Materials & Interfaces. 2019, 11: 6829–6839.
11. Chuanfeng Teng, Jianbo Jia, Zhiping Wang, Virender K.Sharma, BingYan*. Size-dependent maternal-fetal transfer and fetal developmental toxicity of ZnO nanoparticles after oral exposures in pregnant mice. Ecotoxicology and Environmental Safety. 2019, 182: 109439.
12. Jianqiao Wang, Yusuke Tanaka, Haruka Ohno, Jianbo Jia, Toshio Mori, Tangfu Xiao, Bing Yan, Hirokazu Kawagishi, Hirofumi Hirai*. Biotransformation and detoxification of the neonicotinoid insecticides nitenpyram and dinotefuran by Phanerochaete sordida YK-624. Environmental Pollution. 2019, 252: 856–862.
13. Jianbo Jia, Yi Zhang, Yan Xin, Cuijuan Jiang, Bing Yan*, Shumei Zhai*. Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy. Frontiers in Oncology. 2018, 8: 404.
14. Hainan Sun, Jianbo Jia, Cuijuan Jiang, Shumei Zhai*. Gold nanoparticle-induced cell death and potential applications in nanomedicine. International Journal of Molecular Sciences. 2018, 19: 754.
15. Jianbo Jia, Feifei Li, Hongyu Zhou, Yuhong Bai, Sijin Liu, Yiguo Jiang, Guibin Jiang, Bing Yan*. Oral exposure to silver nanoparticles or silver ions may aggravate fatty liver disease in overweight mice. Environmental Science & Technology. 2017, 51(16): 9334–9343.
16. Jianbo Jia, Feifei Li, Shumei Zhai, Hongyu Zhou, Sijin Liu, Guibin Jiang, Bing Yan*. Susceptibility of overweight mice to liver injury as a result of the ZnO nanoparticle-enhanced liver deposition of Pb2+. Environmental Science & Technology. 2017, 51 (3): 1775–1784.
17. Jianbo Jia, Cuijuan Jiang, Bing Yan*. Potential nanotoxicity in susceptible populations: Insight from investigation of mouse models. Chinese Science Bulletin. 2017, 62: 2749–2757.
18. Jianhua Ge, Yi Zhang, Zhirui Dong, Jianbo Jia, Jiannan Zhu, Xiaoyuan Miao, Bing Yan*. Initiation of targeted nanodrug delivery in vivo by a multifunctional magnetic implant. ACS Applied Materials & Interfaces. 2017, 9: 20771–20778.
19. Yin Liu, Gaoxing Su, Fei Wang, Jianbo Jia, Shuhuan Li, Linlin Zhao, Yali Shi, Yaqi Cai, Hao Zhu, Bin Zhao, Guibin Jiang, Hongyu Zhou*, Bing Yan*. Elucidation of the molecular determinants for optimal perfluorooctanesulfonate adsorption using a combinatorial nanoparticle library approach. Environmental Science & Technology. 2017, 51: 7120–7127.
20. Fei Li, Xiaofei Zhou, Hongyu Zhou, Jianbo Jia, Liwen Li, Shumei Zhai*, Bing Yan*. Reducing both Pgp overexpression and drug efflux with anti-cancer gold-paclitaxel nanoconjugates. PloS ONE. 2016, 11: e0160042.
21. Yongyi Wei, Yang Li, Jianbo Jia, Yiguo Jiang, Bin Zhao, Qiu Zhang*, Bing Yan*. Aggravated hepatotoxicity occurs in aged mice but not in young mice after oral exposure to zinc oxide nanoparticles. NanoImpact. 2016, 3: 1–11.
22. Guixin Cui, Yan Xin, Xin Jiang, Mengqi Dong, Junling Li, Peng Wang, Shumei Zhai, Yongchun Dong, Jianbo Jia, Bing Yan*. Safety profile of TiO2-based photocatalytic nanofabrics for indoor formaldehyde degradation. International Journal of Molecular Sciences. 2015, 16: 27721–27729.
23. Chengke Zhang#, Shumei Zhai#, Ling Wu, Yuhong Bai, Jianbo Jia, Yi Zhang, Bin Zhang, Bing Yan*. Induction of size-dependent breakdown of blood-milk barrier in lactating mice by TiO2 nanoparticles. PloS ONE. 2015, 10: e0122591.
24. Yi Zhang, Yuhong Bai, Jianbo Jia, Ningning Gao, Yang Li, Ruinan Zhang, Guibin Jiang, Bing Yan*. Perturbation of physiological systems by nanoparticles. Chemical Society Reviews. 2014, 43: 3762–3809.
25. Cuijuan Jiang, Jianbo Jia, Shumei Zhai*. Mechanistic understanding of toxicity from nanocatalysts. International Journal of Molecular Sciences. 2014, 15: 13967–13992.
26. Wenwei Wang, Cuijuan Jiang, Ledong Zhu, Nana Liang, Xuejiao Liu, Jianbo Jia, Chengke Zhang, Shumei Zhai, Bin Zhang*. Adsorption of bisphenol A to a carbon nanotube reduced its endocrine disrupting effect in mice male offspring. International Journal of Molecular Sciences. 2014, 15: 15981–15993.
专著：
Jianbo Jia, Bing Yan*. Hepatic Injuries Induced by Engineered Nanomaterials, in Bioactivity of Engineered Nanoparticles. Editors, Bing Yan, Hongyu Zhou, Jorge Gardea-Torresdey. Springer. 2017, 321–338.
专利：
1. 贾建博；张晓俐；吴彦鑫；张伟；闫兵；纳米银制剂在改善高脂饮食诱导的肥胖相关低度炎症和肠道菌群紊乱中的应用，中国发明专利，公告号：CN 112043680 A
2. 贾建博；马戈；吴彦鑫；闫兵；一种贴壁细胞倒置培养装置，中国实用新型专利，专利号：ZL 2019 2 1557664.2
3. 闫兵；袁晓如；张秋；江翠娟；闫希亮；贾建博；王深清；翟淑梅；胡春；周丽；一种基于碳纳米材料的空气颗粒污染物模型及其应用，中国发明专利，专利号：ZL 2018 1 1217526.X
4. 闫兵；王芳；翟淑梅；江翠娟；贾建博；王深清；刘寅；胡春；周丽；一种赖氨酸衍生分子化合物修饰的金纳米颗粒及其应用，中国发明专利，公告号：CN 109364099 A
