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闫兵教授-环境健康研究团队负责人

【来源: | 发布日期:2022-08-16 】


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闫兵

博士,教授,博士生导师

教育部长江学者特聘教授

广州大学大湾区环境研究院环境健康研究所所长(团队负责人)

Fellow of Royal Society of Chemistry

Co- Editor-in-Chief, Ecotoxicology and Environmental Safety

地址:广州市越秀区桂花岗东1号广州大学,510405

E-maildrbingyan@yahoo.com

教育背景

1978.02-1982.01 山东大学化学系,学士

1986.09-1989.10 美国哥伦比亚大学,M.A.

1986.09-1990.10 美国哥伦比亚大学,M.Phil.

1989.09-1990.10 美国哥伦比亚大学,Ph.D.

研究方向

环境毒理与健康

科研项目

1.        国家自然科学基金重点项目:“纳米细胞效应的大数据构建及智能模拟预测”(项目编号:22036002,执行年限:2021.01-2025.12

2.        广东省“珠江人才计划”引进创新创业团队-饮用水安全保障团队:“饮用水健康风险识别与控制原理”(项目编号:2019ZT08L387,执行年限:2020-2025

3.        国家重点研发计划纳米专项:“水污染治理所用纳米材料的生物安全性”(课题编号:2016YFA0203103,执行年限:2016.07-2021.06

4.        国家自然科学基金重大研究计划重点项目:“细颗粒物与生物界面作用机制的系统探索”(项目编号:915432042016-2019年)

5.        国家自然科学基金重大研究计划重点项目:“非编码RNA在大气细颗粒物致气道炎症反应中的作用机制研究”(项目编号:916432042016-2020年)

6.        中国科学院B类战略性先导科技专项:“典型污染物的环境暴露与健康危害机制”,协作课题“细颗粒物引起细胞氧化应激及免疫毒性的机制及健康效应关联”(项目编号:XDB140304012014-2019年)

7.        国家重大基础研究(973)课题:目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价(项目编号:2010CB9335042010-2014年)

8.        国家自然科学基金重点项目:典型纳米材料的生物毒性效应及调控研究(项目编号:211370022012-2016年)

9.        国家自然科学基金面上项目:环境中碳纳米管生物毒性的分子机制与调控研究(项目编号:210770682011-2013年)

10.    国家自然科学基金重大研究计划培育项目:选择性治疗耐药性肺癌的噻唑烷酮类小分子探针化合物的设计、合成及其体内外抗癌活性研究与机制探讨(项目编号:909130062010-2012年)

发表论文、专著、专利及奖励

闫兵教授当前的主要研究领域为环境毒理与环境健康。他出版英文专著11部,并在Nature NanotechnologyChemical ReviewsChemical Society ReviewsNature CommunicationsJournal of the American Chemical SocietyNano LettersACS NanoAdvanced Functional MaterialsEnvironmental Science & Technology等学术期刊上发表论文320余篇(详见团队网站:http://www.yanlab.net)。

 

近期代表性论文:

1.        Mu Q, Jiang G, Chen L, Zhou H, Fourches D, Tropsha A & Yan B.*, Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems. Chemical Reviews 2014, 114(15):7740-81.

2.        Wang Y, Yan B, Chen L. SERS Tags: Novel Optical Nanoprobes for Bioanalysis. Chemical Reviews 2013, 113(3), 1391-1428.

3.        Zhang Y, Bai Y, Jia J, Gao N, Li Y, Zhang R, Jiang G, Yan B.*, Perturbation of Physiological Systems by Nanoparticles. Chemical Society Reviews 2014, 28(3):296-305.

4.        Wei P, Pan X, Chen C, Li H, Yan X, Li C, Chu Y*, Yan B*. Emerging Impacts of Ionic Liquids on Eco-Environmental Safety and Human Health.Chemical Society Reviews. 2021, 50, 13609-13627

5.        Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch E, Snyder S, Yan B.* Repeated carbon nanotube administrations in male mice cause reversible testis damage without affecting fertility. Nature Nanotechnology 2010, 5(9), 683-689.

6.        Jiao P, Zhou H, Otto M, Mu Q, Li L, Su G, Zhang Y, Butch E, Snyder S, Jiang G, Yan B.* Leading Neuroblastoma Cells to Die by Multiple Premeditated Attacks from a Multifunctionalized Nanoconstruct. Journal of the American Chemical Society 2011, 133(35), 13918-13921.

7.        Li L, Zhang Q, Liu A, Li X, Zhou H, Liu Y, Yan B.* Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule. Journal of the American Chemical Society 2011, 133(18), 6886-6889.

8.        Zhou H, Jiao P, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. Journal of the American Chemical Society 2011, 133(4), 680-682.

9.        Bai, X., Wang, S., Yan, X., Zhou, H., Zhan, J., Liu, S., Sharma, V. K., Jiang, G., Zhu, H., Yan, B.*, Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries. ACS Nano 2020, 14, (1), 289-302.

10.    Wang W, Sedykh A, Sun H, Zhao L, Russo D, Zhou H, Yan B*, Zhu H*. Predicting Nano-bio Interactions by Integrating Nanoparticle Libraries and Quantitative Nanostructure Activity Relationship Modeling. ACS Nano. 2017. 11 (12) :1264112649.

11.    Gao N, Zhang Q, Mu Q, Bai Y, Li L, Zhou H, Butch E, Powell T, Snyder S, Jiang G, Yan B*, Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity. ACS Nano 2011, 5(6), 4581-4591.

12.    Wu L, Zhang Y, Zhang C, Cui X, Zhai S, Liu Y, Li C, Zhu H, Qu G, Jiang G, Yan B.* Tuning Cell Autophagy by Diversifying Carbon Nanotubes Surface Chemistry. ACS Nano, 2014, 8(3): 2087-99.

13.    Mu Q, Du G, Chen T, Zhang B, Yan B.* Suppression of Human Bone Mophorgenetic Protein (BMP) Signaling by Carboxylated Single-Walled Carbon Nanotubes. ACS Nano 2009, 3(5), 1139-1144.

14.    Mu Q, Broughton D, Yan B.* Endosomal Leakage and Nuclear Translocation of Multiwalled Carbon Nanotubes: Developing a Model for Cell Uptake. Nano Letters 2009, 9(12), 4370-4375.

15.    Zhang B, Xing Y, Zhou H, Li Z, Mu Q, Yan B.* Functionalized Carbon Nanotubes Specifically Bind to Chymotrypsin Catalytic Site and Regulate its Enzymatic Function. Nano Letters 2009, 9(6), 2280-2284.

16.    Zhou H, Mu Q, Gao N, Liu A, Xing Y, Gao S, Zhang Q, Qu G, Chen Y, Liu G, Zhang B, Yan B*. A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Letters 2008, 8(3), 859-865.

17.    Yan X., Sedykh A., Wang W., Yan B.*, Zhu H.* Construction of a web-based nanomaterial database by big data curation and modeling friendly nanostructure annotations. Nature Communications. 2020, 11, 2519.

18.    Zhang Y, Wang Y, Liu A, Xu L, Zhao B, Zhang Y, Zou H, Wang W, Zhu H and Yan B.*, Modulation of Carbon Nanotubes Perturbation to the Metabolic Activity of CYP3A4 in the Liver, Advanced Functional Materials 2016, 26:841-850.

19.    Wang Z, Zhang C, Huang F, Liu X, Wang Z* and Yan B*. Breakthrough of ZrO2 nanoparticles into fetal brains depends on developmental stage of maternal placental barrier and fetal blood-brain-barrier. Journal of Hazardous Materials, 2020. 402, 123563.

20.    Pan X, Li L, Huang H, Wu J, Zhou X, Yan X, Jia J, Yue T*, Chu Y*, Yan B*. Biosafety-Inspired Structural Optimization of Triazolium Ionic Liquids Based on Structure-Toxicity Relationships. Journal of Hazardous Materials. 2021, 424, 127521.

21.    Wang J, Zhang J, Gao Y, Xiong H, Zhang W*, Yan B*. The ZrO2 NPs enhanced the risk of arsenate by promoting accumulation and limiting biotransformation of arsenate from Daphnia magna to zebrafish. Journal of Hazardous Materials. 2021, 424, 127338.

22.    Wang H, Liu C, Liang Z, Zhu L, Xu G, Chen C, Ma K, Liu R, Zhou L*, Yan B*. A TbPO4-Based Environmental Extracellular Antibiotic Genes Capturer through Interrogating Lanthanide Phosphate Nanoneedles. Journal of Hazardous Materials. 2021, 423, 127139.

23.    Kong L, Wu Y, Li C, Liu J, Jia J, Zhou H*, Yan B*. Nano-Cell and Nano-Pollutant Interactions Constitute Key Elements in Nanoparticle-Pollutant Combined Cytotoxicity. Journal of Hazardous Materials. 2021, 418, 126259.

24.    Liu F, Wang Z, Wei Y, Liu R, Jiang C, Gong C, Liu Y*, Yan B*. The Leading Role of Adsorbed Lead in PM2.5-Induced Hippocampal Neuronal Apoptosis and Synaptic Damage. Journal of Hazardous Materials. 2021, 416, 125867.

25.    Pan X, Wu J, Jiang C, Yu Q, Yan B*. Synergistic effects of carbon nanoparticle-Cr-Pb in PM2.5 cause cell cycle arrest via upregulating a novel lncRNA NONHSAT074301.2 in human bronchial epithelial cells. Journal of Hazardous Materials. 2021, 411, 5, 125070.

26.    Wei Y, Sun H*, Zhang S, Xie Q, Li C, Zhao B, Yan B*. Multi-walled carbon nanotubes inhibit potential detoxification of dioxin-mediated toxicity by blocking the nuclear translocation of aryl hydrocarbon receptor. Journal of Hazardous Materials. 2022, 430, 128458.

27.    Zhou, X., Jia, J., Luo, Z., Su, G., Yue, T., Yan, B.*, Remote Induction of Cell Autophagy by 2D MoS2 Nanosheets via Perturbing Cell Surface Receptors and mTOR Pathway from Outside of Cells. ACS Applied Materials & Interfaces 2019, 11, (7), 6829-6839.

28.    Jia, H., Li, S., Wu, L., Li, S., Sharma, V. K., Yan, B.*, Cytotoxic Free Radicals on Air-Borne Soot Particles Generated by Burning Wood or Low-Maturity Coals. Environmental Science & Technology. 2020, 54, 9, 5608–5618.

29.    Pan, X., Yuan, X., Li, X., Gao, S., Sun, H., Zhou, H., Hou, L., Peng, X., Jiang, Y.*, Yan, B.*, Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb2+-Containing Model PM2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1. Environmental Science & Technology 2019, 53, (8), 4566-4578.

30.    Yan J, Yan X*, Hu S, Zhu H, Yan B*. Comprehensive Interrogation on Acetylcholinesterase Inhibition by Ionic Liquids Using Machine Learning and Molecular Modeling. Environmental Science & Technology. 2021, 55, 21, 14720–14731.

31.    Wang X, Qin Y, Li X, Yan B*, Martyniuk CJ. A comprehensive interrogation of metabolic and bioenergetic responses of early staged zebrafish (Danio rerio) to a commercial copper hydroxide nanopesticide. Environmental Science & Technology. 2021, 55, 19, 13033–13044.

32.    Liu G, Yan X, Wang S, Yu Q, Jia J*, Yan B*. Elucidation of critical role of core materials in PM2.5-induced cytotoxicity through interrogating silica- and carbon-based model PM2.5 particle libraries. Environmental Science & Technology. 2021, 55, 19, 13033–13044.

33.    Zhou X, He S, Gao Y, Chi H, Wang D, Li Z, Yan B*. Quantitative Analysis of Polystyrene and Poly(Methyl Methacrylate) Nanoplastics in Tissues of Aquatic Animals. Environmental Science & Technology. 2021, 55, 5, 3032–3040.

34.    Kang Y, Su G*, Yu Y*, Cao J, Wang J, Yan B*. CRISPR-Cas12a-based Aptasensor for On-site and Highly Sensitive Detection of Microcystin-LR in Freshwater. Environmental Science & Technology. 2022, 56, 7, 4101–4110

35.    Zhou X, Jiang L, Wang D, He S, Li C, Yan B*, Speciation Analysis of Ag2s- and ZnS-Nanoparticles and ng/L Level in Environmental Waters by Cloud Point Extraction Coupled with LC-ICPMS. Analytical Chemistry. 2020. 92, 7, 4765-4770.

代表性专著:

1.        Yan, B., Zhou, H. Gardea-Torresdey, J. (2017) Bioactivity of Engineered Nanoparticles by Springer-Nature.

2.        Yan, B., Zhang, B. (2010) Analytical methods in combinatorial chemistry, Second Edition by Francis and Taylor Group.

3.        Yan, B. and Czarnik, AW, Series Editors (2009) Critical Review in Combinatorial Chemistry Volume 5. Chen, T. High-Throughput Screening Technologies by Francis and Taylor Group.

4.        Yan, B. and A. W. Czarnik, Series Editors (2008) Critical Review in Combinatorial Chemistry Volume 4. Wang, P. High-Throughput Analysis in Pharmaceutical Industry by Francis and Taylor Group.

5.        Yan, B. and A. W. Czarnik, Series Editors (2008) Critical Review in Combinatorial Chemistry Volume 3. Tushar A. Kshirsagar Editor, High-Throughput Lead Optimization in Drug Discovery. by Francis and Taylor Group.

6.        Yan, B. and A. W. Czarnik, Series Editors (2005) Critical Review in Combinatorial Chemistry Volume 2. Armen M. Boldi, Editor, Combinatorial Synthesis of Natural Product Based Libraries. by Francis and Taylor Group.

7.        Yan, B. and A. W. Czarnik, Series Editors (2005) Critical Review in Combinatorial Chemistry Volume 1. Radislav A. Potyrailo, Wilhelm Maier. Editors, Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials. by Francis and Taylor Group.

8.        Yan, B. Editor (2003) Chemical Analysis  A Series of Monographs on Analytical Chemistry and Its Applications Volume 163 Analytical and purification methods in Combinatorial Chemistryby John Wiley and Sons, Inc. Highlighted by:Journal of Natural Products, 2004, Vol. 67, No. 6, 1076.Angew. Chem. Int. Ed. 2004, 43, 4552 4553. Drug Development And Industrial Pharmacy, 2004, Vol. 30, No. 7, p. 793.

9.        Yan, B. and Czarnik, A. Editors (2001) Optimization of solid-phase combinatorial synthesis by Marcel Dekker, New York. Highlighted by J. AM. CHEM. SOC. 9 VOL. 124, NO. 26, 2002 7875.

10.    Gremlich, H. U. and Yan, B. Editors (2000) Biological FTIR and Raman Spectroscopy by Marcel Dekker, New York. Highlighted by J. Am. Chem. Soc., Vol. 123, No. 42, 2001 10427.

11.    Yan, B. (1999) Analytical methods in combinatorial chemistry by CRC Press (former Technomics). Highlighted by Journal of Medicinal Chemistry, 2001, Vol. 44, No. 20, 3334.

授权专利:

1.        一种二茂铁酰胺类分子化合物修饰的金纳米颗粒在制药中的应用。已授权;授权公告日期:20201117日;专利号:ZL 2018 1 1216416.1

2.        一种基于碳纳米材料的空气颗粒污染物模型及其应用。已授权;授权公告日期:2020519日;专利号:ZL 2018 1 1217526.X

3.        5-(4-羟基-3-甲氧基苯亚甲基)-2-(2-硝基苯亚胺基)噻唑烷酮及应用。已授权;授权公告日期:201989日;专利号:ZL 2017 1 0186484.7

4.        2-(4-三氟甲基苯亚胺基)-5-(2-萘基亚甲基)噻唑烷-4-酮化合物及应用。已授权;授权公告日期:201989日;专利号:ZL 2017 1 0184406.3

5.        一种具有多样化空间构型与π电子密度的配体分子化合物及其应用。已授权;授权公告日期:2019716日;专利号:ZL 2017 1 1021047.6

6.        一种具有表面多样性的金纳米颗粒系列化合物。已授权;授权公告日期:2019716日;专利号:ZL 2017 1 0168630.3

7.        一种噻唑烷酮化合物及其在制备治疗铁紊乱相关疾病药物中的应用。已授权;授权公告日期:2016420日;专利号:ZL 2014 1 0698860.7

8.        一种空间位阻结构单一变化的金纳米颗粒阵列及其应用。已授权;授权公告日期:20151028日;专利号:ZL 2014 1 0464969.4

9.        一种能清除全氟污染物的金纳米颗粒阵列。已授权;授权公告日期:2016127日;专利号:ZL 2014 10169811.4

10.    一种具有克服和避免P糖蛋白介导的肿瘤多药耐药性双重作用的金纳米药物载体。已授权;授权公告日期:20151028日;专利号:ZL 2014 1 0075010.1

11.    噻唑烷酮衍生物及其在制备抗肺癌药物中的应用。已授权;授权公告日期:201457日;专利号:ZL 2012 1 0205143.7

12.    新型吡啶并硫氮七元环衍生物作为抗肿瘤药物、及其制备方法和应用。已授权;授权公告日期:201592日;专利号:ZL 2011 1 0141898.0

13.    一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法。已授权;授权公告日期:2013717日;专利号:ZL 2011 1 0074869.7

14.    2-苯醚基亚氨基-5-(2-羟基-苯甲基)-1, 3-噻唑-4-酮在制备抗脑癌药物中的应用。已授权;授权公告日期:2011119日;专利号:ZL 2010 1 0124664.0

15.    一种抗肺癌的药物组合物。已授权;授权公告日期:20111116日;专利号:ZL 2010 1 0115656. X

科技奖励:

1.        闫兵(1/4);典型纳米材料的生物效应及调控方法原理,山东省人民政府,自然科学一等奖,2019 (闫兵;周宏钰;陈令新;江桂斌)

闫兵(1/1); Shaping Activity through Structural Modification: From Small Molecules to Nanoparticles, Award for Scientific Excellence from the Division of Environmental Chemistry of the American Chemical Society, 2018 (闫兵).