王晓红

博士，副教授，硕士生导师

广州大学青年拔尖人才

第十五届最受欢迎教师

广州大学 广州大学城外环西路230号，510006

E-mail：wangxh@gzhu.edu.cn

教育背景

2016.09 - 2017.09 佛罗里达大学，环境与人类毒理学研究中心，联合培养博士研究生

2013.09 - 2018.06 东北师范大学，环境学院，博士

2009.09 - 2013.06 东北师范大学，环境学院，学士

工作经历

2018.10-至今 广州大学大湾区环境研究院，副教授

研究方向

1. 环境污染物的水生生态毒理学

2. 环境污染物的毒性作用机制和有害结局路径

科研项目

[1] 国家自然科学基金面上项目：可溶性有机质共存下重金属硫化物纳米颗粒的水生生物富集和神经发育毒性研究，2025/01-2028/12，50万，在研，主持。

[2] 国家自然科学基金青年项目：基于AMPK信号通路研究Cu(OH)₂纳米农药诱导斑马鱼仔鱼能量代谢失衡的分子调控机制，2023/01-2025/12，30万，在研，主持。

[3] 广东省自然科学基金面上项目：氢氧化铜纳米农药对斑马鱼能量代谢内稳态失衡的分子调控机制研究，2022/01-2024/12，10万，结题，主持。

[4] 广东省自然科学基金面上项目：Pyrethroids类纳米农药对斑马鱼胚胎的神经发育毒性及机制研究，2021/01-2023/12，10万，结题，主持。

[5] 广州市基础与应用基础研究专题（青年博士“续航”项目）：嗜球果伞素类杀菌剂对鱼类生殖毒性的分子机制研究，2024/01-2025/12，10万，在研，主持。

[6] 广州市基础与应用基础研究专题（青年博士“启航”项目）：多孔载体材料装载Pyrethroids类纳米农药对斑马鱼胚胎的神经发育毒性及机制研究2021/04-2023/04，5万，结题，主持。

[7] 广州市高校科技类研究生科研项目：可溶性有机质共存下重金属硫化物纳米颗粒在斑马鱼体内的定量分析方法研究，2025/01-2026/12，2万，在研，主持。

[8] 广州大学引进人才科研启动项目：水环境中纳米氧化锌对斑马鱼能量代谢的干扰效应及作用机制研究，2019/01-2021/12，30万，结题，主持。

[9] 广州市高等学校教学改革项目课程思政示范课程项目：绚丽极地风光，2023/06-2025/06，2万，结题，主持。

发表论文和专利

(1) Ye Xiaolin, Xie Yizhen, Liang Zhenda, Wang Shenqing, Zhou Li, Wang Xiaohong*, Christopher J. Martyniuk, Yan Bing. Hypochlorite-driven oxidative dissolution boosts neurodevelopmental toxicity of cadmium sulfide nanoparticles in zebrafish. Environ. Sci. Technol. 2025, 59, 12008-12021

(2) Chen Siying, Qin Yingju, Ye Xiaolin, Liu Jian, Yan Xiliang, Zhou Li, Wang Xiaohong*, Christopher J. Martyniuk, Yan Bing. Neurotoxicity of the Cu(OH)₂ nanopesticide through perturbing multiple neurotransmitter pathways in developing zebrafish. Environ. Sci. Technol. 2023, 57, 19407-19418.

(3) Wang Xiaohong, Qin Yingju, Li Xiaoyu, Yan Bing*, Christopher J. Martyniuk. Comprehensive interrogation of metabolic and bioenergetic responses of early-staged zebrafish (Danio rerio) to a commercial copper hydroxide nanopesticide. Environ. Sci. Technol. 2021, 55, 13033-13044.

(4) Xie Yizhen, Wang Xiaohong*, Wang Shenqing, Wang Jiahui, Zhou Li*, Yan Bing. Enhancing effect of humic acid on neurodevelopmental impact of cadmium sulfide nanoparticles to zebrafish. J. Hazard. Mater. 2025, 498, 139947.

(5) Wang Xiaohong, Qin Yingju, Chen Siying, Wen Yuting, Ye Xiaolin, Jia Jianbo*, Zhou Hongyu*, Yan Bing. Unveiling the role of adenosine monophosphate-activated protein kinase (AMPK) signaling in managing energetic and metabolic responses to Cu(OH)₂ nanopesticide in zebrafish. Environ. Sci. Technol. Lett. 2024, 11, 60-66.

(6) Xu Yongtao, Wang Haiqing, Ye Sheng, Liang Zhenda, Chen Zhiquan, Wang Xiaohong*, Zhou Li*, Yan Bing. Goethite adaptation prompts alterations in antibiotic susceptibility and suppresses development of antibiotic resistance in bacteria. Sci. Total Environ. 2024, 916, 170248.

(7) Mao Xuan, Liu Yujiao, Wei Yongyi, Li Xiaodi, Liu Yin, Su Gaoxing, Wang Xiaohong*, Jia Jianbo*, Yan Bing. Threats of per- and poly-fluoroalkyl pollutants to susceptible populations. Sci. Total Environ. 2024, 921, 171188.

(8) Li Xiaoyu¹, Qin Yingju¹, Kong Long, Yan Xiliang, Zhang Wei, Christopher J. Martyniuk*, Wang Xiaohong*, Yan Bing. Metabolomic and bioenergetic responses of human hepatocellular carcinoma cells following exposure to commercial copper hydroxide nanopesticide. Environ. Sci. Nano. 2022, 9, 589-605.

(9) Kong Long, Wang Xiaohong*, Li Xiaoyu, Liu Jian, Huang Xinxin, Qin Yingju, Che Xin, Zhou Hongyu*, Christopher J. Martyniuk, Yan Bing. Aggravated toxicity of copper sulfide nanoparticles via hypochlorite-induced nanoparticle dissolution. Environ. Sci. Nano. 2022, 9, 1439-1452.

(10) Wang Xiaohong, Chen Siying, Qin Yingju, Wang Haiqing, Liang Zhenda, Zhao Yuanhui, Zhou Li*, Christopher J. Martyniuk. Metabolic responses in livers of female and male zebrafish (Danio rerio) following prolonged exposure to environmental levels of zinc oxide nanoparticles. Aquat. Toxicol. 2022, 253, 106333.

(11) Wang Xiaohong, Li Xiaoyu, Wang Yue, Qin Yingju, Yan Bing*, Christopher J. Martyniuk.. A comprehensive review of strobilurin fungicide toxicity in aquatic species: Emphasis on mode of action from the zebrafish model. Environ. Pollut. 2021, 275, 116671.

(12) Chen Siying, Wang Xiaohong*, Ye Xiaolin, Qin Yingju, Wang Haiqing, Liang Zhenda, Zhu Lishan, Zhou Li*, Christopher J. Martyniuk., Yan Bing. Dopaminergic and serotoninergic neurotoxicity of lanthanide phosphate (TbPO₄) in developing zebrafish. Chemosphere. 2023, 340, 139861.

(13) Wang Xiaohong, Fan Lingyun, Wang Shuo, Wang Yue, Yan Lichen, Zheng Shanshan, Christopher J. Martyniuk*, Zhao Yuanhui*. Relationship between acute and chronic toxicity for prevalent organic pollutants in Vibrio fischeri based upon chemical mode of action. J. Hazard. Mater. 2017, 338, 458-465.

(14) Qin Yingju, Wang Xiaohong*, Yan Xiliang*, Zhu Di, Wang Jia, Chen Siying, Wang Shuo, Wen Yang, Christopher J. Martyniuk., Zhao Yuanhui*. Developmental toxicity of fenbuconazole in zebrafish: Effects on mitochondrial respiration and locomotor behavior. Toxicology. 2022, 470, 153137.

(15) Li Xiaoyu, Qin Yingju, Wang Yue, Huang Tao, Zhao Yuanhui, Wang Xiaohong*, Christopher J. Martyniuk*, Yan Bing. Relative comparison of strobilurin fungicides at environmental levels: Focus on mitochondrial function and larval activity in early staged zebrafish (Danio rerio). Toxicology. 2021, 452, 152706.

(16) Wang Xiaohong, Souders II Christopher, Xavier Priscilla, Li Xiaoyu, Yan Bing*, Christopher J. Martyniuk*. The pyrethroid esfenvalerate induces hypoactivity and decreases dopamine transporter expression in embryonic/larval zebrafish (Danio rerio). Chemosphere. 2020, 243, 125416.

(17) Wang Xiaohong, Souders II Christopher, Zhao Yuanhui*, Christopher J. Martyniuk*. Paraquat affects mitochondrial bioenergetics, dopamine system expression, and locomotor activity in zebrafish (Danio rerio). Chemosphere. 2018, 191, 106-117.

(18) Wang Xiaohong, Zheng Shanshan, Huang Tao, Su Limin, Zhao Yuanhui*, Souders II Christopher, Christopher J. Martyniuk*. Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae. Chemosphere. 2018, 210, 633-644.

教授课程

《环境毒理与健康风险》（研究生专业课，32学时/考察）

《环境基因组学技术和方法》（本科生专选课，16学时/考察）

《绮丽极地风光》（本科生通识课，16学时/考察）

学生培养

研究生：指导硕士研究生毕业4名，在读5名。